Introduction
In 2019 the novel coronavirus started a pandemic and ever since millions
have been affected in the respiratory system and other organs like the
skin. Ever since the first vaccines got authorized for use, many people
have become immune to severe forms of infection and many lives have been
saved [1]. However, complications and side effects of the vaccines
were also reported [2]. Even though cutaneous reaction to vaccines
is not a novel concept and many reactions are known to have happened,
some reactions are more severe and require intensive care. COVID-19
Vaccine-induced TEN is a rare incidence on its own and only a few cases
have been reported [3].
Toxic epidermal necrolysis is an idiosyncratic drug reaction that is
associated with high mortality and morbidity rates [4 5]. This
spectrum of diseases is heralded by an acute fever which is followed by
a generalized dusky rash, crusting, extensive erosion, conjunctivitis,
necrolysis of the epidermis, mucositis, In both the pulmonary and
gastrointestinal tract [5] [6]. It is estimated that the
mortality of TEN is around 30%. Several drugs such as sulfonamides,
anti-convulsive medications, and even influenza vaccines are known to be
chiefly associated with this reaction; however, vaccines are among the
least associated causes [5] [7].
In this article, we report a case of TEN following the administration of
the Sinopharm COVID-19 vaccine. TEN is an important entity even though
it has rarely been reported with COVID-19 vaccines. The current report
will also provide a brief review of the literature concerning the
reported TEN/SJS cases that are induced by a COVID-19 vaccine.