D1 receptor antagonist ecopipam in children and adolescents (Gilbert D et al: Selective D1 receptor antagonism: clinical trial of a novel
treatment for Tourette Syndrome. Mov Disord 2018 [in press]).
Clinical and neuropsychological studies
Other
Treatment
Psychological interventions
Medication
Neurosurgery
- Efficacy and Safety of Deep Brain Stimulation in Tourette Syndrome: The International Tourette Syndrome Deep Brain Stimulation Public Database and Registry \citep{Martinez_Ramirez_2018}. This report summarizes information on 185 Tourette patients from 10 countries. Mean improvement in total YGTSS score was 40% at 6 months after vs. before surgery, and 45% at 12 months. The difference between stimulation sites (CM-Pf, anterior GPi, posterior GPi) was not statistically significant. About a third of patients had side effects, mostly related to stimulation not surgery.