Abstract

Fanconi anemia (FA) is a rare, multi-organ cancer-prone inherited bone marrow failure syndrome (IBMFS) associated with hematological malignancies and solid tumors. The androgen therapy, hematopoietic growth factors, hematopoietic stem cell transplantation (HSCT), and gene therapy (GT), still in the clinical trial, are various treatments for this disease. Here, we aimed to compare the advantages and disadvantages of HSCT and GT in FA cures.
We perform an advanced electronic search of ”Fanconi anemia” AND (genetics OR treatment OR HSCT OR GT OR Mosaicism), and ”Allo-HSCT” AND (conditioning regimen OR complications OR GvHD OR infection OR cost) MeSH terms in non-citation and citation databases. Besides, the gray literature was searched too. This article will provide a summary of the advantages and disadvantages of HSCT and GT of FA disease.
Our results show that GT has a good potential in FA treatments in the future. Furthermore, it has higher advantages and fewer disadvantages in comparison with HSCT.
Systematic Review Registration: CRD42021247364 ID on PROSPERO database.
Keywords: Fanconi Anemia, Hematopoietic Stem Cell Transplantation, Gene Therapy, Comparison.