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Targeting Mitochondrial Proteases for Therapy of Acute Myeloid Leukemia
  • +1
  • Xinrong Xiang,
  • Rui Bao,
  • Yu Wu,
  • Youfu Luo
Xinrong Xiang
Sichuan University West China Hospital
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Rui Bao
Sichuan University West China Hospital
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Yu Wu
Sichuan University West China Hospital
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Youfu Luo
Sichuan University West China Hospital
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Abstract

Targeting cancer metabolism has emerged as an attractive approach to improve therapeutic regimens in acute myeloid leukemia (AML). Mitochondrial proteases are closely related to cancer metabolism, but their biological functions have not been well characterized in AML. According to different catogory, we comprehensively reviewed the role of mitochondrial proteases in AML. This review highlights some ‘powerful’ mitochondrial protease targets, including their biological function, chemical modulators, and applicative prospect in AML.
25 Nov 2021Submitted to British Journal of Pharmacology
26 Nov 2021Submission Checks Completed
26 Nov 2021Assigned to Editor
03 Dec 2021Reviewer(s) Assigned
01 Feb 2022Review(s) Completed, Editorial Evaluation Pending
03 Feb 2022Editorial Decision: Revise Minor
01 Mar 20221st Revision Received
15 Mar 2022Submission Checks Completed
15 Mar 2022Assigned to Editor
16 Mar 2022Review(s) Completed, Editorial Evaluation Pending
17 Mar 2022Editorial Decision: Accept
30 Mar 2022Published in British Journal of Pharmacology. 10.1111/bph.15844