Caffeine and Bronchopulmonary dysplasia:Clinical Benefits and Its Mechanisms
Yuan Yuan ;Yang yang ;Xiaoping Lei ;Wenbin Dong
1 Division of Neonatology,Department of Pediatrics,The Affiliated Hospital of Southwest Medical University, Luzhou, China
2 Department of Perinatology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
3 Sichuan Clinical Research Center for Birth Defects, The Affiliated Hospital of Southwest Medical University, Luzhou, China
Address for correspondence Wenbin Dong MD, Xiaoping Lei MD,Division of Neonatology, Department of Pediatrics, Southwest Medical University,No.8 Section 2,Kangcheng Road ,Luzhou, Sichuan 646000,people’s Republic of China (email:dongwenbin2000@163.com)
Funding information National Natural Science Foundation of China, Grant/Award Number: 81571480; Luzhou Municipal People’s Government‐SouthwestMedical University Science and Technology Strategic Cooperation Project, Grant/Award Number: 2020LZXNYDJ03
Abstract 】:
Bronchopulmonary dysplasia (BPD) is a chronic respiratory disease caused by a combination of prenatal and postnatal factors that leads to the disruption of lung development and abnormal repair, this is a condition that is commonly seen in premature infants. With the improvement of treatment technology, the survival rate of very early preterm infants has increased significantly compared with before, and the incidence of severe BPD has decreased, however, the prevalence of BPD has not decreased. The overall prevalence of BPD is 45%.The prevention of prematurity, the systematic use of non-aggressive ventilator measures, the avoidance of supra-physiological oxygen exposure, and the administration of diuretics, caffeine and vitamin A have all been shown to lead to a significant reduction in the risk of BPD development. A growing number of clinical studies have shown that caffeine not only prevents apnea, but also reduces the incidence of BPD. We review the clinical value of caffeine in the treatment of BPD and its potential mechanisms of action, include anti-inflammatory, antioxidant, anti-fibrotic, anti-apoptotic pathways, and the regulation of angiogenesis. Our aim was to provide a new theoretical basis for the clinical treatment of BPD.
Key words :Caffeine, Bronchopulmonary dysplasia , Anti-inflammatory, Antioxidant , Anti-fibrotic, Anti-apoptotic