Eastern European lineage
Thirty-four SNPs (14 intronic, 20 exonic) were found in Eastern European populations, from which 3 were non-synonymous and 17 synonymous (Fig. 5 and Table S7). Although highly significant p -values for some correlations between Tshr SNP frequencies and environmental proxies were found in the Eastern European lineage, R2-values are extremely low (0.1±0.02, mean±SD). This indicates that in Eastern European voles, Tshr SNP frequencies weakly correlate with geographical distance, latitude, longitude, altitude and pCPP (Fig. 5, Table S7). This observation indicates that genetic Tshr variation in Eastern Europe is unlikely to be explained by natural selection due to seasonal variance.