Eastern European lineage
Thirty-four SNPs (14 intronic, 20 exonic) were found in Eastern European
populations, from which 3 were non-synonymous and 17 synonymous (Fig. 5
and Table S7). Although highly significant p -values for some
correlations between Tshr SNP frequencies and environmental
proxies were found in the Eastern European lineage,
R2-values are extremely low (0.1±0.02, mean±SD). This
indicates that in Eastern European voles, Tshr SNP frequencies
weakly correlate with geographical distance, latitude, longitude,
altitude and pCPP (Fig. 5, Table S7). This observation indicates that
genetic Tshr variation in Eastern Europe is unlikely to be
explained by natural selection due to seasonal variance.