1. INTRODUCTION
Familial Mediterranean fever (FMF) is an autoinflammatory disease, associated with mutations in the Mediterranean fever (MEFV) gene with an autosomal recessive pattern of inheritance, and mainly affects populations of eastern Mediterranean descent1. It is characterized by recurrent self-limited attacks of fever and serosal inflammation as well as the development of amyloidosis 1,2. Patients with FMF may also have non-amyloid renal involvement including typical acute post-streptococcal glomerulonephritis (APSGN) 3. APSGN is an important non-suppurative, immunologically mediated complication of streptococcal infection4and presents with the sudden onset of gross hematuria, edema, and hypertension with variable degrees of renal impairment5. Vasculitic diseases such as polyarteritis nodosa (PAN) also affect the kidneys in FMF6. PAN is a primary multisystem inflammatory disorder characterized by acute necrotizing vasculitis of the small and medium-sized visceral arteries and their branches with a pauci-immune pattern 7,8, and it may develop in children with FMF7,9. Here, we report a previously healthy patient, newly diagnosed with FMF and with co-existing APSGN and PAN.