4. CONCLUSION
This exceptional case constitutes a rare presentation of FMF with
co-existing systemic PAN and APSGN. Since FMF is an autoinflammatory
disease and streptococcal infections frequently trigger FMF attacks, all
three conditions may be preceded by a streptococcal infection. The
homozygous M694V mutation in our patient caused an augmented response to
streptococcal antigens, leading to APSGN and PAN. This clinical
presentation also confirmed the role of GAS in the etiology of systemic
PAN.
CONSENT: Written informed consent was obtained from the
patient’s parents to publish this report in accordance with the
journal’s patient consent policy.
AUTHOR CONTRIBUTIONS: YÖA, BED and SAB were actively involved
in the clinical care of the patient and wrote the manuscript.
ACKNOWLEDGMENTS: The authors wish to thank parents of the child
in this case for their cooperation.
CONFLICT OF INTEREST: All authors declare that they have no
competing interests.