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Comparative analysis of the complete mitochondrial genomes of four cordyceps fungi
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  • can zhong,
  • jian jin,
  • rongrong zhou,
  • hao liu ,
  • jing xie,
  • dan wan,
  • shengen xiao,
  • shuihan zhang
can zhong
Hunan Academy of Chinese Medicine

Corresponding Author:[email protected]

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jian jin
Hunan Academy of Chinese Medicine
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rongrong zhou
Hunan Academy of Chinese Medicine
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hao liu
Hunan Academy of Chinese Medicine
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jing xie
Hunan Academy of Chinese Medicine
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dan wan
Hunan Academy of Chinese Medicine
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shengen xiao
Hunan Agricultural University
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shuihan zhang
Hunan Academy of Chinese Medicine
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Cordyceps is a large group of entomogenous, medicinally important fungi. In this study, we sequenced, assembled, and annotated the entire mitochondrial genome of O. xuefengensis, in addition to comparing it against three other complete cordyceps mitogenomes that were previously published. Comparative analysis indicated that the four complete mitogenomes are all composed of circular DNA molecules, although their sizes significantly differ due to high variability in intron and intergenic region sizes in the O. sinensis and O. xuefengensis mitogenomes. All mitogenomes contain 14 conserved genes and two ribosomal RNA genes, but varying numbers of tRNA introns. The Ka/Ks ratios for all 14 PCGs and rps3 were all less than 1, indicating that these genes have been subject to purifying selection. Phylogenetic analysis was conducted using concatenated amino acid and nucleotide sequences of the 14 PCGs and rps3 using two different methods (Maximum Likelihood and Bayesian analysis), revealing highly supported relationships between O. xuefengensis and other Ophiocordyceps species, in addition to a close relationship with O. sinensis. Further, the analyses indicated that cox1 and rps3 play important roles in population differentiation. These mitogenomes will allow further study of the population genetics, taxonomy, and evolutionary biology of medicinally important cordyceps species.
16 Nov 2021Submitted to Ecology and Evolution
18 Nov 2021Submission Checks Completed
18 Nov 2021Assigned to Editor
23 Nov 2021Reviewer(s) Assigned
04 Dec 2021Review(s) Completed, Editorial Evaluation Pending
07 Mar 2022Editorial Decision: Revise Minor
22 Mar 20221st Revision Received
22 Mar 2022Submission Checks Completed
22 Mar 2022Assigned to Editor
22 Mar 2022Review(s) Completed, Editorial Evaluation Pending
22 Mar 2022Reviewer(s) Assigned
28 Mar 2022Editorial Decision: Accept
Apr 2022Published in Ecology and Evolution volume 12 issue 4. 10.1002/ece3.8818