5. Conclusion
This study represented that newly designed RS fusion peptide could
improve NC-mediated siRNA delivery targeting breast cancer cells. RS
peptides could form self-assembled NCs with siRNAs via electrostatic
attraction, hydrophobic interaction, and hydrogen bonding. Formed RS-NCs
exhibited prolonged stability, enhanced cellular uptake, and target gene
silencing by siRNAs. Resultantly, RS-NC-mediated siRNA delivery
successfully inhibited breast cancer cell growth specifically and
effectively. In addition, RS peptide was proved as cytocompatible, and
RS-NC showed biosafety and no inflammation in vivo . Therefore,
the RS-NC could be expected to become a promising siRNA delivery
platform for breast cancer or other cancer treatment.