5. Conclusion
This study represented that newly designed RS fusion peptide could improve NC-mediated siRNA delivery targeting breast cancer cells. RS peptides could form self-assembled NCs with siRNAs via electrostatic attraction, hydrophobic interaction, and hydrogen bonding. Formed RS-NCs exhibited prolonged stability, enhanced cellular uptake, and target gene silencing by siRNAs. Resultantly, RS-NC-mediated siRNA delivery successfully inhibited breast cancer cell growth specifically and effectively. In addition, RS peptide was proved as cytocompatible, and RS-NC showed biosafety and no inflammation in vivo . Therefore, the RS-NC could be expected to become a promising siRNA delivery platform for breast cancer or other cancer treatment.