Literature Search Strategy
This systematic review was performed and reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement [10]. We searched in PubMed and MEDLINE (https://www.ncbi.nlm.nih.gov/pubmed/) with time point set to end of May 2021 using medical subject headings and text words supplemented by scanning the bibliographies of recovered articles included “type A acute aortic dissection”, “acute type A dissection”, “cerebral malperfusion”, “brain malperfusion”, “stroke” and using the Boolean word “AND”. Prior to data extraction, all titles, abstracts and full texts were sequentially reviewed following inclusion criteria. Moreover, the reference lists of the selected articles were manually screened and reviewed to identify further relevant citations. Two co-authors (CW and LZ) reviewed and selected relevant articles for inclusion. Differences were resolved in consensus discussions. In order to avoid duplicates, all included studies were independently assessed and critically evaluated. Additional hand searching was undertaken.