Abstract
Background : CO2 laser and the 532-nm potassium
titanyl phosphate laser (KTP) were developed to treat Laryngeal
papillomatosis (LP); however, the difference in their outcomes remains
unclear.
Methods : A systematic review was conducted through a
comprehensive search of three databases.
Results : Overall, the cure rates were 87.25% in the KTP group
and 75.98% in the CO2 group (p<0.05). The
complications rates were significantly different between the two groups
(p<0.0001). In addition, there was no significant difference
between the recurrence rates of the CO2 group and the
KTP group (10% vs 9.8%). The risks of bias were 13.1±1.45 and
13.6±1.52 for CO2 group and KTP group respectively,
which indicated the fair quality of evidence.
Conclusions : The available fair-quality evidence suggested that
KTP laser excision may be a better choice for LP. Following evaluations
on the benefits of the two
surgical techniques with more high-quality randomized controlled studies
are needed.
Keywords : Laryngeal papillomatosis; Recurrent respiratory
papillomatosis; 532-nm potassium titanyl phosphate laser; CO2 laser;
Systematic Review