CONCLUSION
In conclusion, obesity could impair oocyte quantity and quality in
younger women through altered endocrinology and poor follicular
microenvironment, which, in turn, impairs CLBR. Maternal obesity is also
closely associated with HDP and fetal macrosomia among younger women,
which could raise the birth risk and economic burden. Since being
overweight and obese adversely affects IVF/ICSI outcomes, weight loss
management may improve pregnancy outcomes and safety among younger women
with elevated BMI. Further randomized controlled trials of lifestyle or
pharmacological interventions prior to IVF/ICSI procedures in overweight
and obese women are needed to determine whether the short- and long-term
adverse effects for both mothers and their offspring could be reduced.