Patients
We performed a retrospective study on women who were first treated at
the Reproductive Medicine Center of Tongji Hospital
from January 1, 2014, to December 31,
2017. This was a non-interventional, single-center cohort study of
patients undergoing routine long gonadotropin-releasing hormone (GnRH)
agonist protocol. Patient information was anonymous without any
identifier at the time of retrospective chart review.
BMI was expressed as the weight in kilograms divided by the square of
the height in meters (kg/m2). Based on the World
Health Organization classification, all patients with normal (18.5–24.9
kg/m2) and high (≥ 25 kg/m2) BMI who
underwent their first fresh IVF/ICSI cycles were included in the
analysis. Moreover, women with polycystic ovary syndrome (PCOS) or
uterine factors such as intrauterine adhesion and mediastinum uterus
were excluded, and all cycles with
IVF+ICSI fertilization, donor oocyte,
freeze eggs, and preimplantation genetic diagnosis/preimplantation
genetic screening were not included. Finally, a total of 7701 women were
enrolled and were followed up to May 2020, until either delivery of one
live infant or discontinuation of treatment. A total of 464 patients did
not achieve live birth but had frozen embryos from the first
stimulation, and eight women were pregnant. Finally, 7229 women
completed the follow-up (Fig. S1).