Introduction:
Adverse cutaneous drug reactions involve a variety of clinical manifestations, ranging from minor skin rashes to fatal hypersensitivity reactions. Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS), is one of these manifestations. This pathology, which can lead to death in 10% of cases [1][2], is commonly overlooked and misdiagnosed [3].
Through this paper, a case of Allopurinol-induced DRESS syndrome with initial oral mucosal involvement is presented while emphasizing the importance of early diagnosis to achieve the appropriate management.