Table 4: Japanese group’s criteria for diagnosis of DRESS / DIHS
Developing maculopapular rash >3 weeks starting with the suspected drug. Prolonged clinical symptoms 2 weeks after discontinuation of the suspected drug Fever >38 °C Liver abnormalities (ALT>100U/L)* Leucocyte abnormalities (at least one present) (a)Leukocytosis (>11*10^9 /L) (b) Atypical lymphocytosis(>5%) (c) Eosinophilia(>1,5 *10^9 /L) Lymphadenopathy Human Herpes 6 reactivation Diagnosis is confirmed by the presence of the 7 criteria (typical DIHS) or the five (1-5) (atypical DIHS). *: This can be replaced by other organ involvement, such as renal involvement.