Author contribution:
Ben salha wahbi: data collection and interpretation
Eya moussaoui : aquisation and analysis of data and drafting the manuscript
Ouaha lamia: revising the manuscript for important intellectual content
Anoun jihed: collection and interpretation of data
Nabiha douki: conception and design and revising the manuscript
Key clinical message: In DRESS syndrome, drug history and the timing of apparition of muco-cutaneous lesions are the keys to diagnosis. Systemic symptoms and negative Nikolsky’s sign are two clinical indicators differenciating DRESS from other maculopapular drug eruptions.