1-Hospitalization*
2-Reaction suspected to be drug-related*
3- Acute rash*
4-Fever >38 °C ↑
5- Enlarged lymph nodes at a minimum of 2 sites
6- Involvement of at least 1 internal ↑
7- Blood count abnormalities ↑
-Lymphocytes above or below normal limits
-Eosinophils above the laboratory limits
-Platelets below the laboratory limits.
*Necessary criteria required for making diagnosis.
↑ Three out of four criteria are required
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