Discussion
COVID-19 vaccination efforts have been increasing resulting in many receiving mRNA vaccines. The COVID-19 mRNA vaccine encodes for the spike glycoprotein of the virus. The vaccine’s liquid suspension particles allow for direct delivery of mRNA into host cells. Once intracellular, the mRNA upregulates ribosomal activity to create the spike glycoprotein.1 The spike glycoprotein is then presented on the surface of the cell, this subsequently triggers the immune system to produce antibodies specific to the spike protein.1,2 COVID-19 vaccine side effects are typically mild and may involve local injection site pain, myalgia, and fatigue. Serious adverse effects are rare, but recent reports have suggested that mRNA COVID-19 vaccines may cause myocarditis, pericarditis, and myopericarditis. As of June 11th 2021, the Centers for Disease Control (CDC) have identified 323 cases of myocarditis, pericarditis, and myopericarditis in the United States.3 CDC findings suggest that afflicted patients are more likely to be male, younger with a median age of 19 years, and experience symptoms within two days after vaccination.3 The most common presenting symptoms include chest pain (85%-95%), fever (65%) dyspnea (19%-49%), and syncope (6%).4 The CDC also determined that patients were more likely to be hospitalized, but clinical course was mild as most patients recover fully .3,5 While no consensus mechanism has been elucidated, vaccine component hypersensitivity, inflammatory reaction, and inappropriate immune system activation have been mentioned as potential causes.4 Perimyocarditis diagnosis requires fulfillment of 2 out of 4 major criteria: pleuritic chest pain, auscultation of pericardial rub, ECG changes, and effusion on imaging.6 Additionally, patients must also have elevated biomarkers suggestive of myocardial injury (troponin) and reduced left ventricular function.4 Our patient presented with pleuritic chest pain, characteristic ECG changes, effusion on imaging, minor LV dysfunction, and biomarker elevation. Imaging with Echo and CMR are useful for diagnosis and informing clinical course. Echo can identify the presence of effusion as well as be used for risk stratification in patients with cardiac tamponade.7 Findings of pericarditis on CMR include T1-weighted enhancement of the thickened pericardium, T2-weighted increased pericardial intensity, and presence of pericardial edema on delayed hyperenhancement (DHE).8 Notably, CMR findings of DHE in patients who develop non-vaccine myocarditis is associated with increased risk of cardiac complications.9Therefore, assessing the long term risk of complications in patients who have DHE on CMR after vaccination is paramount.9 While much is still unknown about management of perimyocarditis in patients after COVID-19 vaccination, patients are treated using current guidelines for pericarditis management (non-steroidal anti-inflammatory drugs, colchicine, and/or steroids). Luckily, our patient was able to achieve clinical improvement on this regimen alone. Biologics (rilonacept) are indicated in patients who develop dependence on NSAIDs, colchicine, and steroids.10To our knowledge, this is one of the first reports of perimyocarditis after COVID-19 vaccination. Fortunately, these patients seem to experience mild disease courses. However, further observational studies are required to understand the side effects associated with COVID-19 vaccination.