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Similarity and Consistency Assessment of Three Major Online Drug-Drug Interaction Resources
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  • Elpida Kontsioti,
  • Simon Maskell,
  • Amina Bensalem,
  • Bhaskar Dutta,
  • Munir Pirmohamed
Elpida Kontsioti
University of Liverpool

Corresponding Author:[email protected]

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Simon Maskell
University of Liverpool
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Amina Bensalem
Ceva Santé Animale
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Bhaskar Dutta
AstraZeneca Gaithersburg
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Munir Pirmohamed
University of Liverpool Institute of Translational Medicine
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AIM: To explore the level of agreement on drug-drug interaction (DDI) information listed in three major online drug information resources (DIRs) in terms of: (1) interacting drug pairs; (2) severity rating; (3) evidence rating and (4) clinical management recommendations. METHODS: We extracted DDI information from the British National Formulary (BNF), Thesaurus, and Micromedex. Following drug name normalisation, we estimated the overlap of the DIRs. We annotated clinical management recommendations either manually, where possible, or through application of a machine learning algorithm. RESULTS: The DIRs contained 51,481 (BNF), 38,037 (Thesaurus), and 65,446 (Micromedex) drug pairs involved in DDIs. The number of common DDIs across the three DIRs was 6,970 (13.54% of BNF, 18.32% of Thesaurus, and 10.65% of Micromedex). Micromedex and Thesaurus overall showed higher levels of similarity in their severity ratings, while the BNF agreed more with Micromedex on the critical severity ratings and with Thesaurus on the least significant ones. Evidence rating agreement between BNF and Micromedex was generally poor. Variation in clinical management recommendations was also identified, with some categories (i.e. Monitor and Adjust dose) showing higher levels of agreement compared to others (i.e. Use with caution, Wash-out, Modify administration). CONCLUSIONS: There is considerable variation in the DDIs included in the examined DIRs, together with variability in categorisation of severity and clinical advice given. DDIs labelled as critical are more likely to appear in multiple DIRs. Such variability in information could have deleterious consequences for patient safety, and there is a need for harmonisation and standardisation.
03 Oct 2021Submitted to British Journal of Clinical Pharmacology
04 Oct 2021Submission Checks Completed
04 Oct 2021Assigned to Editor
22 Nov 2021Reviewer(s) Assigned
08 Dec 2021Review(s) Completed, Editorial Evaluation Pending
25 Jan 2022Editorial Decision: Revise Major
15 Mar 20221st Revision Received
16 Mar 2022Submission Checks Completed
16 Mar 2022Assigned to Editor
16 Mar 2022Review(s) Completed, Editorial Evaluation Pending
17 Mar 2022Reviewer(s) Assigned
28 Mar 2022Editorial Decision: Accept
Sep 2022Published in British Journal of Clinical Pharmacology volume 88 issue 9 on pages 4067-4079. 10.1111/bcp.15341