Introduction:Cyclopia (synophthalmia) is a fatal uncommon congenital abnormality.1-3 It is the severest case of holoprosencephaly (HPE).1,3-7 During the organogenesis, the embryonic prosencephalon is divided partially or never into the right and left cerebral hemispheres,2,3which leads to the pilgrims not being divided into double separate caves.1,4,7-9 This happens between the eighteenth and the twenty-eighth day of pregnancy.1,4,7,8 The incidence is 1.05 per 100,000 births including stillbirth1 with a tendency to occur in females8. Clinically, there are typical craniofacial features including a single or imperfectly cleft eye in one orbit, nasal agenesis or proboscis, which is a non-functional nose located above the central orbit and that is known as Rhinocephaly.1-3,6,9,10 Furthermore, the extracranial characteristics along with Cyclopia, for instance, polydactyly, renal dysplasia, Omphalacele1,2,6 also cardiac malformations such as ventricle septum defect (VSD).10 Synophthalmia is possible to develop for no specific reason7 or due to risk factors such as exposure to deformed substances during pregnancy10, diabetes, infections6, and genetic mutations6,10. This case is incompatible with life4,5,7 either abortion or stillbirth or dying several hours after birth.1,3,8,10 Diagnosis began from the 22nd week of pregnancy6 by ultrasound (US).4-7 The most common syndrome associated with Cyclopia is Patau (trisomy 13)3,10. Herein, we present a unique case of alobar holoprosencephaly with cyclopia which was diagnosed after miscarriage.

Title pageSuccessful management of 15 years late-onset Cytomegalovirus infection complicated with deep venous thrombosis in a kidney transplant patient: a rare case report and a review of the literature

Clival Ectopic Pituitary Prolactinoma was Successfully Managed by Transsphenoidal Surgery: A Rare Case Report

Successful Surgical Management of Symptomatic Antenatally Diagnosed Congenital Pulmonary Airway Malformation: A Case Report

Multiple myeloma is a hematological cancer mostly located in the marrow of the vertebrae, pelvis, and thighs. Although the presence of extramedullary disease in the central nervous system is rare, herein, we report a complicated case of multiple myeloma in the spinal cord.

Morgagni’s hernia is a congenital diaphragmatic hernia, which represents only 3 % of all diaphragmatic hernias. Herein, we report a case of a 28-years old symptomatic female with Morgagni’s hernia who underwent a trans-abdominal surgery using a mesh placed.

Bladder Rhabdomyosarcoma is a rare disease. It can be diagnosed by imaging and histological examination and managed using multi-modal therapy. Herein, we report a large non-metastatic rhabdomyosarcoma mass positioned in the bladder which was successfully eradicated through open surgery.

Poliomyelitis is a viral infection that may lead to paralysis or death. Paralysis can lead to skeletal and joint deformities. Typical manifestations include equinos cavus and tibial shortening. We report a polio case presented with right equinus foot, clawing in the right great toe, and shortening in the right tibia.