Background
Many autoimmune diseases have been reported to be associated with Ulcerative Colitis (UC). The association between UC and systemic lupus erythematosus (SLE) has been rarely reported in some case reports, however, none of them consider a relationship or a link between UC and SLE. This may be due to SLE colitis may mimic UC and some drugs for UC treatment, particularly sulphasalazine, may cause drug-induced SLE [1 2]. In addition, the serum protein electrophoresis of the patients with SLE usually shows polyclonal gamma globulin rises due to hyperactivity of B-Lymphocytes and monoclonal gammopathy is a rare finding in serum electrophoresis in a few cases [1 3]. In this case report, we reported a patient with a past medical history of UC and diagnosed with SLE and revealed monoclonal gammopathy in serum electrophoresis. To the extent of our knowledge, this is the first case of a UC that has been diagnosed with SLE and monoclonal gammopathy simultaneously.