Background
Many autoimmune diseases have been reported to be associated with
Ulcerative Colitis (UC). The association between UC and systemic lupus
erythematosus (SLE) has been rarely reported in some case reports,
however, none of them consider a relationship or a link between UC and
SLE. This may be due to SLE colitis may mimic UC and some drugs for UC
treatment, particularly sulphasalazine, may cause drug-induced SLE [1
2]. In addition, the serum protein electrophoresis of the patients
with SLE usually shows polyclonal gamma globulin rises due to
hyperactivity of B-Lymphocytes and monoclonal gammopathy is a rare
finding in serum electrophoresis in a few cases [1 3]. In this case
report, we reported a patient with a past medical history of UC and
diagnosed with SLE and revealed monoclonal gammopathy in serum
electrophoresis. To the extent of our knowledge, this is the first case
of a UC that has been diagnosed with SLE and monoclonal gammopathy
simultaneously.