Insulin Therapy:
Insulin is the treatment of choice for DIDM secondary to glucocorticoids and L-asparaginase(29)(36). It is suggested to begin insulin therapy once diagnosis of DIDM is entertained. Table-2 (supplementary file) enlists different types of insulin, onset, peak and duration of action after subcutaneous injection. Children presenting with or developing DKA should be managed with the existing standard guidelines for acute management with intravenous fluids and insulin infusion(41). It is prudent to document pattern of hyperglycaemia and tailor made the therapy. Insulin regimen, dose, and duration should be guided by pattern of hyperglycaemia, child’s age and the severity of metabolic derangements.