Author contribution :
  1. Faiza CHBEL : conception , interpretation, redaction and submission
  2. Hicham CHARROUTE: molecular modelling analysis and revising manuscript
  3. Redouane BOULOUIZ : sanger sequencing analysis and revising manuscript
  4. Hasna HAMDAOUI: cytogenetic analysis
  5. Houssein MOSSAFA: conception and validation
  6. Houda BENRAHMA: interpretation and revising manuscript
  7. Karim OULDIM: medical advisor, conception and validation