Author contribution :
- Faiza CHBEL : conception , interpretation, redaction and submission
- Hicham CHARROUTE: molecular modelling analysis and revising manuscript
- Redouane BOULOUIZ : sanger sequencing analysis and revising manuscript
- Hasna HAMDAOUI: cytogenetic analysis
- Houssein MOSSAFA: conception and validation
- Houda BENRAHMA: interpretation and revising manuscript
- Karim OULDIM: medical advisor, conception and validation