Baseline and Metabolic Characteristics
A total of 216 patients participated in the study, including 104 PCOS patients and 112 control women. The clinical baseline characteristics of all subjects were summarized in Table 1. Statistically significant differences in age, E2, P, PRL,THS were not found between the two groups(P>0.05). However, compared with control group, there was a significant increase in the levels of BMI, LH, T, dehydroepiandrosterone(DHEA-s), AMH, but a decline in FHS in PCOS group(P<0.05) as expected, which was according with the clinical features of PCOS. Table 2 showed the glucose and lipid metabolic characteristics in participants. LDL, triglyceride(TG), LDL/HDL, ApoB, ApoB/ApoAI, total cholesterol(TC) and TC/HDL levels were elevated in the PCOS group (P<0.05). In other hand, fasting blood glucose(FBG), fasting insulin and HOMA-IR had no statistically significant between two groups (P>0.05).
The expression of ANGPTL4 in ovarian GCs
The expression of ANGPTL4 in ovarian GCs was measured in the two groups by qRT-PCR. Compared with the control women, the expression of ANGPTL4 was significantly increased in the PCOS patients [(1.05±0.60) vs (1.75±1.12), p =0.000] as shown in Fig.1 .