Baseline and Metabolic Characteristics
A total of 216 patients participated in the study, including 104 PCOS
patients and 112 control women. The clinical baseline characteristics of
all subjects were summarized in Table 1. Statistically
significant differences in age, E2, P, PRL,THS were not found between
the two groups(P>0.05). However, compared with control group, there was
a significant increase in the levels of BMI, LH, T,
dehydroepiandrosterone(DHEA-s), AMH, but a decline in FHS in PCOS
group(P<0.05) as expected, which was according with the clinical
features of PCOS. Table 2 showed the glucose and lipid
metabolic characteristics in participants. LDL, triglyceride(TG),
LDL/HDL, ApoB, ApoB/ApoAI, total cholesterol(TC) and TC/HDL levels were
elevated in the PCOS group (P<0.05). In other hand, fasting blood
glucose(FBG), fasting insulin and HOMA-IR had no statistically
significant between two groups (P>0.05).
The expression of ANGPTL4 in ovarian GCs
The expression of ANGPTL4 in ovarian GCs was measured in the two groups
by qRT-PCR. Compared with the control women, the expression of ANGPTL4
was significantly increased in the PCOS patients [(1.05±0.60) vs
(1.75±1.12), p =0.000] as shown in Fig.1 .