Prospective application of novel parameters to validation
cohort
Using CoV ≥ 0.7, the SOO was correctly predicted in 23/29 (79.3%) of
cases (sensitivity 81.0%, specificity 87.5%). Using VE < 50,
the SOO was correctly predicted in 26/29 (89.7%) of cases (sensitivity
90.5%, specificity 87.5%). By comparison, the correct SOO was
predicted in 24/29 (82.8%) of cases with both ECG algorithms: TZI
(sensitivity 81.0%, specificity 87.5%) and
V2S/V3R Index (sensitivity 90.5%,
specificity 62.5%). Overall, VE < 50 had the highest Youden
Index (78) and was the parameter that was most likely to both
successfully predict a RVOT SOO (PPV = 95.0%) and correctly exclude a
LVOT SOO (NPV = 77.8%). (Table 4)