Prospective application of novel parameters to validation cohort
Using CoV ≥ 0.7, the SOO was correctly predicted in 23/29 (79.3%) of cases (sensitivity 81.0%, specificity 87.5%). Using VE < 50, the SOO was correctly predicted in 26/29 (89.7%) of cases (sensitivity 90.5%, specificity 87.5%). By comparison, the correct SOO was predicted in 24/29 (82.8%) of cases with both ECG algorithms: TZI (sensitivity 81.0%, specificity 87.5%) and V2S/V3R Index (sensitivity 90.5%, specificity 62.5%). Overall, VE < 50 had the highest Youden Index (78) and was the parameter that was most likely to both successfully predict a RVOT SOO (PPV = 95.0%) and correctly exclude a LVOT SOO (NPV = 77.8%). (Table 4)