Participants
Participants were part of a larger study examining long-term
neurocognitive, social-emotional, and functional outcomes in pediatric
brain tumor survivors. Participants were enrolled according to the
following eligibility criteria: (1) treated with a single course of PRT
or XRT for a primary brain tumor, (2) no evidence of active disease at
enrollment, (3) age ≥ 6 years at evaluation, and (4) fluent in English.
All participants treated with XRT were treated between 2001 and 2006,
while those treated with PRT were treated between 2007 and 2013. The
timing defined for the two RT groups differed due to a shift from XRT to
PRT as standard of care in 2007 at our institution. Eligible
participants for the parent study were identified via medical record
review and were approached for enrollment between 2011 and 2018. An
87.3% participation rate was achieved for the study. Patients who
declined participation did not significantly differ from enrolled
participants based on RT type, sex, race, or histology (data not shown,
all p > 0.05). Of note, given our interest in
long-term neurocognitive and social outcomes, patients diagnosed with
brain stem glioma, high-grade glioma, or atypical teratoid/rhabdoid
tumors were excluded from participation. Data were also excluded for
participants who could not complete testing due to profound cognitive or
visual impairment (n=5). The present study reports on the outcomes of 58
patients. Medical and demographic characteristics for participants are
reported in Table 1.