Losartan effects on neural activation during anticipation and
outcome phase
No significant main or interaction effects of treatment were observed in
the a priori ROI analyses on extracted parameter estimates during
anticipation. An exploratory whole-brain analysis confirmed the lack of
significant treatment main and interaction effects (atpFWE <0.05). During the outcome phase a
significant treatment times condition effect was observed in the VTA
(F =3.24, p =0.0435), reflecting that LT significantly
increased the difference between reward and neutral (t =2.407,p =0.0172) as well as between reward and punishment
(t =1.924, p =0.056, marginal significant, seesupplementary results ). Significant main effects of condition
during the anticipation and outcome phase see supplementary
results (Figure S1 , Table S1 ).