Functional Connectivity Analysis
To determine the social reward-punishment networks we initially examined neural activity during receipt of feedback [reward+punishment–neutral] in the entire sample. Results revealed that social feedback induced stronger activity in regions involved in salience, value and social processes, including insula, striatum, dorsal medial prefrontal cortex (dmPFC), and occipital lobe (Figure S1C ). Combined with the a priori defined VTA-striatal structural maks three peak coordinates (VS: [22/-6/-10], DS: [-14/-2/-8], VTA: [10/-14/-12]) were identified to construct spherical seeds with 6 mm radius which served as seeds for the generalized psychophysiological interactions (gPPI) analysis (65) (supplementary method ). Treatment effects were determined by comparing the seed-region-specific connectivity maps by means of mixed ANOVA analyses with the factors (condition, treatment) on the whole brain level (separately for each phase). To further disentangle significant interaction effects parameter estimates were extracted from regions exhibiting significant interaction effects involving treatment.