Functional Connectivity Analysis
To determine the social reward-punishment networks we initially examined
neural activity during receipt of feedback
[reward+punishment–neutral] in the entire sample. Results revealed
that social feedback induced stronger activity in regions involved in
salience, value and social processes, including insula, striatum, dorsal
medial prefrontal cortex (dmPFC), and occipital lobe (Figure
S1C ). Combined with the a priori defined VTA-striatal structural maks
three peak coordinates (VS: [22/-6/-10], DS: [-14/-2/-8], VTA:
[10/-14/-12]) were identified to construct spherical seeds with 6 mm
radius which served as seeds for the generalized psychophysiological
interactions (gPPI) analysis (65) (supplementary method ).
Treatment effects were determined by comparing the seed-region-specific
connectivity maps by means of mixed ANOVA analyses with the factors
(condition, treatment) on the whole brain level (separately for each
phase). To further disentangle significant interaction effects parameter
estimates were extracted from regions exhibiting significant interaction
effects involving treatment.