Losartan and experimental effects on motivational significance and affective evaluation
The linear mixed model revealed a significant interaction effect (F =3.706, p =0.025, Figure 2A ) between condition and treatment on reaction times indicating that LT induced significantly stronger differences between social punishment vs social reward as compared to PLC (t =2.679, p =0.007), reflecting a shift in the approach-avoidance motivation of social feedback. The main effects of treatment and condition were not significant.
Examining effects of the experimental manipulation and treatment on the affective evaluation by means of a linear mixed model revealed a significant condition main (F =404.983, p <0.0001,Figure 2B ) and condition times treatment interaction effect (F =4.914, p =0.007) on arousal ratings for outcomes. Post hoc analyses showed that LT increased the reward-punishment difference (t =2.390, p =0.017) and decreased punishment-neutral difference (t =-2.952, p =0.003) relative to PLC. With respect to dislikeability ratings for the outcomes a linear mixed model revealed significant condition main (F =633.848,p <0.0001, Figure 2C ), and condition times treatment interaction effects (F =3.413, p =0.033). Post hoc tests showed that LT increased the punishment-neutral difference (t =2.597, p =0.0095) relative to PLC. No significant treatment main or interaction effects were observed on cue or other outcome ratings (see supplementary results ).