Figure 1 Schematic depiction of the experimental protocols and the experimental paradigm
(A) The entire experimental procedure encompassed baseline assessment, drug administration, assessments before fMRI (corresponding to estimated peak plasma levels) and post fMRI acquisition. Abbreviations: BP = blood pressure, HR = heart rate, LT = losartan, PLC = placebo, STAI = state-trait anxiety inventory, PANAS = positive and negative affect schedule. (B) Schematic representation of the trial structure in the SID paradigm. Each trial started with a 500ms cue presentation (circle, reward trial; square, neutral trials, and triangle, punishment trials) followed by a delay (jittered between 1000 and 3000 ms). Next the target appeared with a duration adjusted to the individual response time. After an inter-stimulus interval (ISI, 2000 ms – target duration) the outcome was presented for 1500 ms, followed by an inter-trial interval (ITI) with a duration jittered between 1000 and 3000 ms. (C) Cues and corresponding outcomes (for display only) per trial type. Social reward feedback was shown in response to fast reactions on reward trails, social punishment feedback was shown in response to slow reactions on punishment trials.