Losartan and experimental effects on motivational significance and
affective evaluation
The linear mixed model revealed a significant interaction effect
(F =3.706, p =0.025, Figure 2A ) between condition
and treatment on reaction times indicating that LT induced significantly
stronger differences between social punishment vs social reward as
compared to PLC (t =2.679, p =0.007), reflecting a shift in
the approach-avoidance motivation of social feedback. The main effects
of treatment and condition were not significant.
Examining effects of the experimental manipulation and treatment on the
affective evaluation by means of a linear mixed model revealed a
significant condition main (F =404.983, p <0.0001,Figure 2B ) and condition times treatment interaction effect
(F =4.914, p =0.007) on arousal ratings for outcomes. Post
hoc analyses showed that LT increased the reward-punishment difference
(t =2.390, p =0.017) and decreased punishment-neutral
difference (t =-2.952, p =0.003) relative to PLC. With
respect to dislikeability ratings for the outcomes a linear mixed model
revealed significant condition main (F =633.848,p <0.0001, Figure 2C ), and condition times
treatment interaction effects (F =3.413, p =0.033). Post hoc
tests showed that LT increased the punishment-neutral difference
(t =2.597, p =0.0095) relative to PLC. No significant
treatment main or interaction effects were observed on cue or other
outcome ratings (see supplementary results ).