Losartan effects on the network level
On the network level significant interaction effects between condition and treatment were found for the VS during anticipation but for the VTA during the outcome phase (all findings passed whole-brainpFWE <0.05, Figure 3 ,Table 2 ). Subsequent post-hoc tests revealed that LT significantly modulated VS-middle frontal gyrus (MFG) connectivity during neutral-punishment (t =2.541, p =0.0119), punishment-reward (t =-3.910, p =0.0001), and between social reward feedback (t =2.451, p =0.0151) processes, with the effects being driven by enhanced coupling during social reward-anticipation. In contrast, LT specifically modulated VTA-networks during outcome, such that LT modulated VTA-insula (left) connectivity during the neutral-punishment pattern (t =2.613,p =0.0098), the punishment-reward pattern (t =-4.671,p <0.0001), the neutral-reward pattern (t =-2.059,p =0.0410), and within social punishment (t =-2.012,p =0.0456) and social reward (t =3.128, p =0.002) respectively. In addition, LT modulated both VTA-insula (right) and VTA-SFG connectivity for neutral-punishment(t =5.023,p <0.0001; t =-3.127, p =0.0021) and punishment-reward patterns (t =-3.683, p =0.0003;t =4.368, p <0.0001, Figure 3C ). Losartan also changed VTA-insula (right) connectivity in social punishment (t =-2.512, p =0.0128) and neutral (t =3.13,p =0.002), VTA-superior frontal gyrus (SFG) connectivity in social punishment (t =3.613, p =0.0004). A direct comparion between treatments revealed consistent effects of LT on processing of social punishment feedback, such that it decreased VTA communication with the bilateral insula, yet enhanced VTA communication with the SFG.