Figure 1 Schematic depiction of the experimental protocols and
the experimental paradigm
(A) The entire experimental procedure encompassed baseline assessment,
drug administration, assessments before fMRI (corresponding to estimated
peak plasma levels) and post fMRI acquisition. Abbreviations: BP = blood
pressure, HR = heart rate, LT = losartan, PLC = placebo, STAI =
state-trait anxiety inventory, PANAS = positive and negative affect
schedule. (B) Schematic representation of the trial structure in the SID
paradigm. Each trial started with a 500ms cue presentation (circle,
reward trial; square, neutral trials, and triangle, punishment trials)
followed by a delay (jittered between 1000 and 3000 ms). Next the target
appeared with a duration adjusted to the individual response time. After
an inter-stimulus interval (ISI, 2000 ms – target duration) the outcome
was presented for 1500 ms, followed by an inter-trial interval (ITI)
with a duration jittered between 1000 and 3000 ms. (C) Cues and
corresponding outcomes (for display only) per trial type. Social reward
feedback was shown in response to fast reactions on reward trails,
social punishment feedback was shown in response to slow reactions on
punishment trials.