Losartan effects on neural activation during anticipation and outcome phase
No significant main or interaction effects of treatment were observed in the a priori ROI analyses on extracted parameter estimates during anticipation. An exploratory whole-brain analysis confirmed the lack of significant treatment main and interaction effects (atpFWE <0.05). During the outcome phase a significant treatment times condition effect was observed in the VTA (F =3.24, p =0.0435), reflecting that LT significantly increased the difference between reward and neutral (t =2.407,p =0.0172) as well as between reward and punishment (t =1.924, p =0.056, marginal significant, seesupplementary results ). Significant main effects of condition during the anticipation and outcome phase see supplementary results (Figure S1 , Table S1 ).