Losartan effects on the social feedback prediction error
The ROI analysis indicated that LT significantly enhanced the social feedback PE in DS (t =2.454, p =0.0162) and VTA (t =2.227, p =0.0286) but not the VS (t =1.264,p =0.2098) compared to PLC (Figure 4 ). Further exploratory whole brain analysis revealed both significant positive and negative social feedback PE modulation in widespread subcortical-cortical networks (Figure 5A & 5B , Table 3 ), while LT enhanced the social feedback PE in a cortical midline and superior temporal network encompassing the precuneus, STG, SFG, MFG, cingulate gyrus and SMA (Figure 5C, Table 3 ).