Volunteers Recruitment
Two cohorts of volunteers were selected, a discovery group (254), and a
validation group (565), both containing individuals who have been
diagnosed with OSCC prior to surgery or chemotherapy and individuals
diagnosed no OSCC, called healthy contrast (HC). Specifically, 154
individuals have OSCC and 100 are HC in the discovery group, and 424
have OSCC and 141 are HC in the validation group. All human subject
research was conducted in compliance with the ethical guidelines
established by the Nanjing Stomatological Hospital, Medical School of
Nanjing University. The race, gender, ages, and body weight index were
strictly matched between the two groups. More details about patients’
clinical demographics can be found in the supplementary information
(Table S1 ).