Acknowledgments
We thank all the patients and healthy volunteers who agreed to participate in the present study and all those who helped us successfully complete the research.
This work was financially supported by Health Commission of Hunan Province ( B2019138, Y.Y.), in part by Social Development Project of Hunan Province Key Research Plan (2020SK3044, J.H.), and Major Scientific and Technological Projects for collaborative prevention and control of birth defects in Hunan Province (2019SK1010, G.H.). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.