Model code:
$PROBLEM final model Adalimumab in adults (De Klaver et al.)
$INPUT ID TIME EVID MDV DV AMT RATE SEX AGE WT ATA
$DATA dataset.csv IGNORE=@
; TIME in hours
; WT: TBW in kg
; SEX: 0 = FEMALE, 1 = MALE
$SUBROUTINE ADVAN2 TRANS2 ; linear 1-cmt oral
$PK
; typical values
TVCL = (THETA(1)/24) * (WT/70)**0.75 * THETA(4)**ATA
TVV = THETA(2) * (WT/70)
TVKA = THETA(3)
KA = TVKA/24
; IIV
CL = TVCL * EXP(ETA(1))
V = TVV * EXP(ETA(2))
; scaling
S2=V
$ERROR
IPRED = F
Y = IPRED*(1+ERR(1)) + ERR(2)
$THETA
0.318775 ; 1 CL/F (L/day)
9.83155 ; 2 V/F (L)
0.375643 ; 3 KA (/day)
4.34751 ; 4 AAA~CL
$OMEGA
0.215418 ; 1 IIV CL
0.301728 ; 2 IIV V
$SIGMA
0.0210676 ; 1 Proportional error
0.380199 ; 2 Additive error
$ESTIMATION METHOD=1 INTERACTION NOABORT MAXEVAL=9999 SIGDIG=3 PRINT=5
$COVARIANCE UNCOND
STROBE Statement—checklist of items that should be included in reports
of observational studies