FluSurver analysis
For further analysis of the HA and NA genes the https://flusurver.bii.a-star.edu.sg/ database was used (i) to detect substitutions relative to the outgroup in the phylogenetic analysis (A/Michigan/45/2015), (ii) to display the position of the mutation(s) in structural models and highlight if mutations are close to common drug, host receptor or antibody binding sites; or if a glycosylation motif is lost or created through a mutation relative to the closest reference A/Brisbane/02/2018.