Factors |
Univariate analysis |
Univariate
analysis |
Univariate analysis |
Multivariate
analysis |
Multivariate analysis |
Multivariate
analysis |
Score |
|
HR |
95% CI |
p* |
HR |
95% CI |
p** |
|
Age at diagnosis, years |
|
|
|
|
|
|
|
≤6 |
1 |
|
|
1 |
|
|
16 |
>6 |
0.6 |
0.5-0.8 |
<0.001 |
0.8 |
0.6-1.0 |
0.030 |
0 |
Race |
|
|
|
|
|
|
|
White |
1 |
|
|
1 |
|
|
5 |
Black |
0.9 |
1.0-1.2 |
0.037 |
0.8 |
1.1-1.2 |
0.035 |
3 |
Other |
1.4 |
0.9-2.0 |
0.111 |
0.6 |
0.3-2.1 |
0.375 |
0 |
Sex |
|
|
|
|
|
|
|
Male |
1 |
|
|
1 |
|
|
|
Female |
1.3 |
1.0-1.5 |
0.028 |
1.1 |
0.9-1.3 |
0.586 |
|
YOD |
|
|
|
|
|
|
|
1998-2008 |
1 |
|
|
|
|
|
|
2009-2016 |
0.9 |
0.8-1.2 |
0.568 |
|
|
|
|
Tumor size, diameter, cm |
|
|
|
|
|
|
|
≤3 |
1 |
|
|
1 |
|
|
0 |
>3 |
4.6 |
2.8-7.6 |
<0.001 |
1.9 |
1.1-3.1 |
0.013 |
4 |
Unknown |
2.8 |
1.7-4.5 |
<0.001 |
1.7 |
1.0-2.8 |
0.037 |
7 |
Histologic grade |
|
|
|
|
|
|
|
Well |
1 |
|
|
1 |
|
|
0 |
Moderately |
0.7 |
0.2-3.0 |
0.669 |
0.8 |
0.2-3.1 |
0.722 |
3 |
Poorly |
3.4 |
0.9-13.2 |
0.075 |
1.5 |
2.1-5.8 |
0.021 |
5 |
Undifferentiated |
4.8 |
1.4-16.6 |
0.013 |
2.1 |
0.6-7.3 |
0.248 |
8 |
Unknown |
2.1 |
0.7-6.7 |
0.189 |
1.3 |
0.4-4.0 |
0.682 |
10 |
Stage |
|
|
|
|
|
|
|
Localized |
1 |
|
|
1 |
|
|
|
Regional |
1.4 |
1.0-1.9 |
0.068 |
1.2 |
0.9-1.7 |
0.292 |
|
Distant |
2.4 |
1.2-4.7 |
0.009 |
1.5 |
0.7-2.9 |
0.275 |
|
Surgery |
|
|
|
|
|
|
|
None |
1 |
|
|
|
|
|
|
Yes |
0.6 |
0.3-1.2 |
0.164 |
|
|
|
|
Radiotherapy |
|
|
|
|
|
|
|
None |
1 |
|
|
1 |
|
|
0 |
Yes |
5.9 |
4.3-8.2 |
<0.001 |
4.7 |
3.3-6.6 |
<0.001 |
100 |
Chemotherapy |
|
|
|
|
|
|
|
None |
1 |
|
|
1 |
|
|
|
Yes |
1.8 |
1.5-2.3 |
<0.001 |
1.0 |
0.8-1.3 |
0.779 |
|