Other adjuvant therapies combined with OIT
We also hoped to analyze the efficacy of other adjuvant therapies
combined with OIT, for example, OIT with baked milk or OIT combined with
omalizumab (OMB). Among our included studies, there was only one study
associated with baked milk and OMB respectively. Esmaeilzadeh and
colleagues[19] used baked milk for OIT, 42
patients underwent exposure to baked milk in form of muffin for 6
months, and then to cheese in form of pizza for another 6 months if
patients could undergo oral challenge test by baked cheese exposure in
form of pizza. By the end of the study, 88.1% (37/42) of the patients
in the case group and 66.7% (28/42) of those in the control group had
developed milk tolerance (p=0.018), and the median wheal size of milk
extract skin prick test (SPT) in case group demonstrated a decrease pre-
and post-baked product in diet [64.3% (27/42) VS 26.2% (11/42),
p= 0.033]. Takahashi and
colleagues[18]investigated the efficacy of OIT
with OMB. In the treatment group, the patients accepted OMB from the
beginning of the study every 2 to 4 weeks until 24 weeks, then OIT was
started after the first 8 weeks of OMB treatment, and was maintained for
32weeks. At weeks 32, all 10 OMB-OIT treated patients and none of the 6
untreated patients passed DBPCFC (p<0.001). A significantly
decreased SPT diameter was found in the OMB-OIT treated group
(P< 0.05).