Other adjuvant therapies combined with OIT
We also hoped to analyze the efficacy of other adjuvant therapies combined with OIT, for example, OIT with baked milk or OIT combined with omalizumab (OMB). Among our included studies, there was only one study associated with baked milk and OMB respectively. Esmaeilzadeh and colleagues[19] used baked milk for OIT, 42 patients underwent exposure to baked milk in form of muffin for 6 months, and then to cheese in form of pizza for another 6 months if patients could undergo oral challenge test by baked cheese exposure in form of pizza. By the end of the study, 88.1% (37/42) of the patients in the case group and 66.7% (28/42) of those in the control group had developed milk tolerance (p=0.018), and the median wheal size of milk extract skin prick test (SPT) in case group demonstrated a decrease pre- and post-baked product in diet [64.3% (27/42) VS 26.2% (11/42), p= 0.033]. Takahashi and colleagues[18]investigated the efficacy of OIT with OMB. In the treatment group, the patients accepted OMB from the beginning of the study every 2 to 4 weeks until 24 weeks, then OIT was started after the first 8 weeks of OMB treatment, and was maintained for 32weeks. At weeks 32, all 10 OMB-OIT treated patients and none of the 6 untreated patients passed DBPCFC (p<0.001). A significantly decreased SPT diameter was found in the OMB-OIT treated group (P< 0.05).