Adverse events
Six studies were included for analyzing the serious adverse events of
OIT. There were only six patients together who experienced serious
adverse events, five from the OIT group and one from the control group,
with a pooled RR of 2.2 (95% CI 0.59, 8.22; p=0.24; Figure 4A), there
is no statistical difference. In addition, there were also six studies
describing non-serious adverse events of OIT, 82.1 % (101/123) in the
OIT group compared to 17.5% (20/114) in the control group, the RR value
was 4.21 (95% CI 2.9, 6.13; p<0.00001; Figure 4B), there is a
statistical difference. We also analyzed epinephrine use and treatment
discontinuation during OIT. There were respectively six and eight
studies included and the RR value was 7.69 (95% CI 2.16, 27.33;
p=0.002; Figure 4C) for epinephrine use and 2.23 (95% CI 0.93, 5.34;
p=0.07; Figure 4D) for treatment discontinuation. There is a statistical
difference for epinephrine use, but not for treatment discontinuation.