The expression of serum inflammatory mediators were up-regulated in OF patients
The occurrence of the vast majority of diseases is caused by inflammation, so we carried out the detection of inflammatory mediators in the serum of OF patients, and the results showed that compare with NC, the OF patients have a higher expression of inflammatory mediators IL-1 (0.3638±0.01917pg/mL vs 0.131±0.011pg/mL, P<0.001), IL-6 (133.7±10.94pg/mL vs 79.59±8.775pg/mL, P<0.001) and TNF-α (1.57±0.14pg/mL vs 6.11±0.77pg/mL ) (Figure 1).