5. Conclusion
As a traditional treatment for PNH, corticosteroids are still the
first-line drug for PNH patients in China. However, how to treat
refractory/relapsed PNH for patients in whom corticosteroids are
ineffective or who are dependent on corticosteroids has always been a
difficult problem for clinicians. For patients with refractory/relapsed
PNH, low-dose combined chemotherapy is an effective choice, which can
reduce the number of PNH clones and allow normal clones to expand to
promote normal hematopoiesis and control hemolytic attack. This is a
promising and widely used therapeutic method at present.