2.3 Clinical efficacy indicators
The two main endpoint evaluation indicators were the stability of hemoglobin levels, which was defined as the maintenance of hemoglobin levels above 60 g/l without blood transfusion within 4 to 8 weeks after chemotherapy), and the change in lactate dehydrogenase level from baseline to 12 weeks (fold increase compared with the normal value). Other prespecified measurements included the proportion of reticulocytes, total bilirubin level, proportion of PNH clone cells and dosage of corticosteroids after chemotherapy during treatment.