Conclusion
In this work, we found that one novel and five recorded mutations in
four genes related to inherited heart diseases. The targeted
next-generation sequencing was applied in this study to detect the
candidate mutations. NGS has been proved to have considerable potential
for both clinic and research use. The exon capture followed by NovaSeq
6000 sequencing was specifically used in our study. Combined
applications of this platform and bioinformatics are very promising and
effective methods for molecular screening of patients with inherited
heard diseases, but it still remains that deficiencies on accuracy and
stability need to be further investigated.