Pharmacological MR blockade in pathological animal models
The available MRAs include the non-selective steroidal MRA spironolactone that also displays hormonal side-effects like gynaecomastia. Eplerenone, a newer steroidal MRA, is more selective than spironolactone. Novel non-steroidal MRA are totally different from the clinically available steroidal MRA, with finerenone being the most intensely studied holding the promise of beneficial CV and renal effects with lower rates of hyperkalemia and negligible hormonal side-effects (Kolkhof and Bärfacker, 2017; Agarwal et al., 2021).