Endothelial cell MR deficient models
Blocking specifically MR in endothelial cells protected against
aldosterone-impaired endothelial function only in aorta (not in
resistance arteries) (Rickard et al., 2014). Moreover, endothelial cell
MR-knockout mice presented reduced cardiac fibrosis and inflammation in
the absence of blood pressure reduction when treated with DOCA/salt
(Rickard et al., 2014). Endothelial MR deletion improved capillary
density in DOCA-treated mice (Lother et al., 2018b). Selective MR
deletion in endothelial cells protected from the decline in systolic
function in response to thoracic aortic constriction (Salvador et al.,
2017). NDF failed to increase mitral valve area, thickness, or
proteoglycan content in mice specifically lacking endothelial MR
expression (Ibarrola et al., 2020b). MR deletion in endothelial cells
decreased the endothelial dysfunction in obese female mice (Davel et
al., 2018). Selective endothelial cells MR deficient mice were protected
against obesity-induced endothelial dysfunction (Schäfer et al., 2013).
Endothelial cell-specific MR ablation also improved hypoxia-induced
pulmonary vascular remodeling to a similar extent as did eplerenone
treatment (Kowalski et al., 2021).