Endothelial cell MR overexpression model
Endothelial cell-restricted overexpression of the MR increased the
contractile response of mesenteric arteries and increased blood pressure
in response to hypertensive agents (Cat et al., 2010). Endothelial
cell-specific MR overexpression in mice reduced atrial thrombus
formation after ferric chloride injury (Lagrange et al., 2014)
suggesting a role for endothelial cell MR as an antithrombotic factor.