Mice models with cell-specific MR deletion or overexpression
The generation of mice with cell-selective MR ablation or overexpression have contributed to the knowledge of the specific roles of MR-mediated cell signaling in normal physiology and in pathological conditions (Bauersachs et al., 2015; Young and Rickard, 2015). The use of specific animal models in which the expression of MR is cell-dependently blocked or overexpressed, helps to understand the role of MR in CV diseases. These experimental models associate hypertension, cardiac hypertrophy, and the development of ventricular fibrosis, revealing the harmful CV impact of cell-specific MR activation or repression.