Pharmacological MR blockade in pathological animal models
The available MRAs include the non-selective steroidal MRA
spironolactone that also displays hormonal side-effects like
gynaecomastia. Eplerenone, a newer steroidal MRA, is more selective than
spironolactone. Novel non-steroidal MRA are totally different from the
clinically available steroidal MRA, with finerenone being the most
intensely studied holding the promise of beneficial CV and renal effects
with lower rates of hyperkalemia and negligible hormonal side-effects
(Kolkhof and Bärfacker, 2017; Agarwal et al., 2021).