Cardiac valve cells
Recently, it has been demonstrated that MR pathway regulates the
phenotypic, molecular, and histological changes of valve interstitial
cells (VICs) and valve endothelial cells (VECs) (Ibarrola et al.,
2020b). In VICs, the effects of aldosterone/MR activation were mediated
by CT-1, whereas the effects of the mineralocorticoid were mediated by
CD14 in VECs. Thus, VIC activation, endothelial-mesenchymal transition
and proteoglycan deposition seem to be MR-dependent mechanisms (Ibarrola
et al., 2020b). Moreover, MRA treated patients with mitral valve
prolapse displayed lower levels of proteoglycans in the mitral valves.
Altogether, MRA treatment appears to be a promising option to reduce
fibromyxomatous alterations in patients with mitral valve prolapse
(Ibarrola et al., 2020b).