Main findings
This large population based matched cohort study estimated the long-term
effects of HRT on the hazards of all-cause mortality of 105,199 healthy
women aged 46 to 65 years at first prescription compared to 224,643
matched healthy controls, using primary care data from 1984 to 2017. Our
study found that during this long follow-up, oestrogen-only HRT was not
associated with significantly increased or decreased hazards of
all-cause mortality in any age group, and combined HRT was associated
with a significantly decreased risk of death from all causes.