Patient Characteristics
Three of the largest Canadian pediatric centers, outside of Quebec: BC Children’s Hospital, Alberta Children’s Hospital and Toronto Hospital for Sick Children submitted data. There were 55 eligible children and median age at diagnosis of PTLD was 9 years (IQR 6-12 years). Patient characteristics are described in Table 1. Nine (16%) children had previously received treatment for PTLD: polymorphic n=6, non-destructive n=3. Monomorphic PTLD developed a median of 48 months (IQR 11.3-84.8) post-SOT. Forty-eight (87%) children had mature B-cell disease: 23 (42%) diffuse large B-cell lymphoma (DLBCL) and 25 (45%) Burkitt lymphoma. Majority of children, 41 (75%), presented with advanced stage III/IV disease.