Introduction
Extra-nodal marginal zone lymphoma (MZL) of MALT type compose 7% of all
non-Hodgkin’s lymphomas.1 Approximately one-third
present as a primary gastric lymphoma; 90% are associated withHelicobacter pylori (H. pylori ).1,2 The
etiology of H. pylori negative lymphoma of MALT type remain
controversial. Differentiating H. pylori negative from H.
pylori lymphoma of MALT type is important in regards to treatment and
prognosis. The incidence of primary MALT lymphoma of the gastric remnant
or gastric pouch is not well defined but appears to be quite rare with
less than 35 cases reported worldwide. In this case report, we discuss
the suspected etiologies, diagnosis, treatment, and outcome of a
36-year-old female found to have H. pylori negative gastric
lymphoma of MALT type. The case is further complicated by history of
Roux-en-Y gastric bypass (RYGB) for treatment of refractory
gastroesophageal reflux disease (GERD).