Di Feng

and 7 more

Objective To investigate the relationship between serum fructose and uric acid levels in patients with polycystic ovary syndrome (PCOS). Design A case-control study. Setting University-affiliated in vitro fertilization clinic. Population 292 patients with PCOS and 482 controls. Main Outcome Measures Serum fructose, uric acid and metabolic measurements. Results Compared with controls, serum fructose and uric acid levels were significantly increased in women with PCOS and patients with PCOS accompanied by metabolic disorders exhibited higher serum fructose and uric acid levels (P < 0.001). Restricted cubic splines indicated that serum uric acid levels linearly and positively correlated with serum fructose levels in women with PCOS (Poverall < 0.001, Pnon-linear = 0.30), whereas no correlation was found in controls (Poverall = 0.712, Pnon-linear = 0.43). Additionally, even after adjusting for confounding factors, serum fructose levels were an independent risk factor for hyperuricemia in patients with PCOS (P = 0.001; odds ratio, 1.380; 95% confidence interval, 1.207–1.577). Conclusions There was a significantly positive association of elevated uric acid levels with serum fructose levels in PCOS and was closely correlated with PCOS-related metabolic disorders, highlighting the importance of further research into the biological mechanisms of fructose and uric acid in the development of PCOS. Funding National Natural Science Foundation of China (No. 82071607 and 32100691); LiaoNing Revitalization Talents Program (No. XLYC1907071); Fok Ying Tung Education Foundation (No. 151039); Key Research and Development Program of Liaoning Province (No. 2018225062); Outstanding Scientific Fund of Shengjing Hospital (No. 202003). Keywords Fructose; Uric acid; PCOS; Metabolic disorder

Wenyan Gao

and 5 more

Background Cell-free DNA, a suitable candidate biomarker forming an emerging field of non-invasive evaluation, has been detected for great clinical applications and increasingly used in obstetrics and gynecology. Objective To describe an intuitive global research trends of cfDNA related literature from a bibliometric perspective, and provide researchers with new research hotspots. Search strategy The literature form PubMed and Web of Science Core Collection (WoSCC) database related to cfDNA from January 1 2017 to December 31 2021 were extracted for co-word and VOSviewer analysis, respectively. Study criteria We selected studies where cfDNA was applied for obstetrics and gynecology, i.e., prenatal diagnosis, preimplantation diagnosis, next generation sequencing technology, mosaicism detection or adverse pregnancy outcomes. Data collection and analysis Bibliographic Item Co-Occurrence Matrix Builder, gCLUTO software and VOSviewer were used to perform bibliometrics analysis. Main results Themes in the third quadrant of strategy diagram, including cell-free nucleic acid sequence analysis for non-invasive prenatal testing and genetic testing, the application of cfDNA in the fields of neoplasms genetics and diagnosis are immature themes which are considered newly emerging themes of cfDNA. VOSviewer results showed the global research trends of cfDNA including authors, institutions, countries, journals and research hotspots. Conclusion By analyzing the research hotspots related to cfDNA, immature themes and emerging hotspots deserve more attention and can be considered as hints when launching new research projects. The five major research hotspots could provide an insight into cfDNA research and valuable information for researchers to identify potential collaborators and partner institutions.

Xiuxia Wang

and 5 more

Objective: To investigate the impact of the uterine corpus inclination on pregnancy outcomes in in vitro fertilization and embryo transfer (IVF-ET). Design: Retrospective cohort study. Setting: University-based reproductive medicine center. Population: 526 patients underwent their first frozen embryo transfer (FET) cycle. Methods: All patients underwent transvaginal ultrasound examination to measure the distance from the midline of uterine cavity to the ultrasound probe, which indirectly reflect the uterine corpus inclination. The uterine corpus tends toward the horizontal position as the average distance increases. Multivariable regression analysis was used to study the effect of the uterine corpus inclination on pregnancy outcomes, even in different embryo stage cohorts as subgroup analysis. Main outcomes measures: Clinical pregnancy rate (CPR), spontaneous abortion rate, and live birth rate (LBR). Results:The patients were grouped according to the quartiles of the average distance distribution (Group 1, ≤ 1.98 cm; Group 2, 1.99-2.19 cm; Group 3, 2.20-2.50 cm; Group 4, ≥ 2.51 cm). There were statistically significant differences in the CPR and LBR between Groups 1 and 4 in the cleavage-stage ET cohort (CPR: adjusted odds ratio [OR] 0.225, 95% confidence interval [CI] 0.068-0.774; LBR: adjusted OR 0.315, 95% CI 0.100-0.996) (P < 0.05). There were no significant differences among the four groups in pregnancy outcomes in the blastocyst transfer cohort (P > 0.05). The cut-off value of 2.146 cm was calculated to predict the pregnancy outcomes in the cleavage-stage ET cohort. Conclusion:The uterine corpus inclination might be an independent risk factor for the success of cleavage-stage ET