Better predictor of vancomycin efficacy among other pharmacokinetic
parameters [21].
Lower risk of vancomycin associated nephrotoxicity [21].
Less vancomycin exposure in AUC target range of 400-600 µg.h/ml in
comparison to the target trough concentration of 15-20 µg/ml [21].
Shorter duration of antibiotic therapy [21].
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Multiple samplings are required.
Difficulty and complexity of AUC calculation.
Controversies regarding the upper limit of AUC.
Target AUC24h/MIC range of 400-600 µg.h/ml cannot be
attributed to other Gram-positive microorganisms that are less
virulent than MRSA [19].
AUC target concentration of >400 µg.h/ml was not
correlated with reduced mortality in severe MRSA infections [19].
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