Relationship between change in fungal status and co-infections
Of the individuals classifed as rare at baseline, 65 (36%) subsequently
had at least one year of frequent fungal infections during the study
period, while 116 (64%) remained rare throughout the study period. Of
the individuals classifed as frequent at baseline, 25 (22%) did not
isolate fungus during the follow-up period. We examined co-infections
with P. aeruginosa and S. maltophilia in patients who
transitioned from rare to frequent fungi. Of the individuals who started
in the rare group and transitioned to frequent (n = 65), 17 had P.
aeruginosa positive cultures. In this group, 71% (12/17) had P.
aeruginosa detected prior to fungal positive culture whereas 29%
(5/17) had a positive fungal culture prior to P. aeruginosadetection. Of the 38 individuals with S. maltophilia, 45%
(17/38) had S. maltophilia detected prior to fungal positive
culture whereas 55% (21/38) had a positive fungal culture prior toS. maltophilia detection.