Laboratory markers used to predict mortality in severe COVID-19
Purpose: In this study, we aimed to evaluate the laboratory
markers used in the diagnosis of COVID-19 and to present the parameters
that can be used to predict mortality.
Material and method: The cases followed in the intensive care
unit due to COVID-19 in our clinic between March 2020 and December 2020
were evaluated retrospectively. A total of 374 patients who met the
study criteria were included in the study. The patients were divided
into two groups as the patients who were discharged from the intensive
care unit with no mortality and patients with a mortal course. Patients
with no mortality constituted Group-1, and patients with a mortal course
constituted Group-2. Demographic, clinical, and laboratory
characteristics of the patients were compared.
Results: The number of patients in group-1 consisting of
patients with no mortality was 148 (39.5%), and the number of patients
in group-2 consisting of patients with mortality was 226 (60.4%). In
the group of patients without mortality, 84 (56.8%) of the patients
were male, while in the mortality group, 127 (56.2%) were male. In the
mortality group, procalcitonin, CRP, BUN, D-dimer, troponin, LDH,
lactate, and INR values were higher, albumin value was lower, and this
difference was statistically significant (p<0.001). In the
logistic regression analysis, PLT and D-dimer were found as the
independent variables of mortality.
Conclusion: We think that the high procalcitonin and D-dimer
values obtained with routinely examined rapid and easily accessible
blood tests of Covid-19 patients may contribute to mortality prediction.
Keywords ; Covid 19, bilirubin, C-reactive protein, white blood
cell, neutrophil-lymphocyte ratio, predictive factors
The ongoing covid-19 pandemic causes many deaths regardless of age. This
study was conducted with the aim of developing laboratory parameters
that can be used to predict mortality. We aimed to guide our valuable
colleagues with simple blood tests taken during the first application of
the patients. We believe that it is not a subject that has been studied
much before.