Method :
This study was a randomized double-blind clinical trial involving 30
patients treated with ART at West Medical Center, Tehran, Iran, who had
experienced immunological failure despite HIV viral suppression.
Patients were divided into two groups of 15. The first group received 2
probiotic capsules daily with a colony count of 10⁹CFU per capsule
containing seven strains (including Lactobacillus casei , Lactobacillus
acidophilus, Lactobacillus rhamnosus , Lactobacillus bulgaricus,
Bifidobacterium breve, Bifidobacterium longum , Streptococcus
thermophiles with prebiotic froctooligosaccharide .
By the end of the month 3, patients were tested for CD4+ count using
flow cytometry and were asked to fill questionnaires concerning the
history of diarrhea or intake of the antibiotic, especially Cotrimoxazol
.
after a one- month washout period the participants who had received
probiotics were switched to placebo, and the participants who had
received placebo were given probiotics for three months, and they were
examined for CD4+ counts seven months after the start of the study.