Abbreviations:
2-APB, 2-aminoethoxydiphenyl borate; A-96, A-967079; ACD, allergic contact dermatitis; AD, atopic dermatitis; AITC, allyl isothiocyanate; ANOVA, one-way analysis of variance; CA, cinnamaldehyde; Cap, capsaicin; cryo-EM, cryoelectron microscopy; DMEM, Dulbecco’s modified Eagle’s medium; DNCB, 2, 4-dinitrochlorobenzene; DNFB, 2, 4-dinitrofluorobenzene; FBS, fetal bovine serum; GFP, Green fluorescent protein; GSK101, GSK1016790A; HBSS, Hanks’ balanced salt solution; HEK293, human embryonic kidney 293; IL-1, interleukin-1; MO, mustard oil; PDB, Protein Data Bank; PGE2, Prostaglandin E2; RFU, relative fluorescence unit; RR, ruthenium red; thermo-TRPs, Thermal transient receptor potentials; TRP, transient receptor potential; TRPA1, Transient receptor potential Ankyrin1; TRPV, TRP vanilloid.
Key words: TRPA1; Nitrobenzene; DNFB; skin sensitizer; contact dermatitis; electrophiles; TRPs