Animals
The male C57BL/6 mice (aged 6-8 weeks, weighing 20 ± 2g) mice we buy are from the Vital River Laboratory Animal Technology Co. Ltd. (Beijing, China). In order to adapt them to the new environment, the mice were raised at least a week in the case of sufficient supply and free intake and has a normal circadian rhythm before the experiment. All animal tests were authorized by the Institutional Animal Care and Use Committee of Qingdao University Health Science Center and were performed in accordance with institutional and national guide-lines for the use and care of animals for experiments.