Introduction:
COVID-19 has newly emerged from Wuhan, China, in December 2019. It became a pandemic after infecting millions of people causing significant morbidity and mortality rates in the world. It caused so many challenges on the social, psychological, and financial aspects. (1) Moreover, it made changes in the way healthcare is delivered. It is primarily a disease of the respiratory tract that causes a wide variety of presentations, ranging from asymptomatic to a more severe picture with ARDS and even death. (2) It is worth mentioning that it can infect other systems as described in the literature. Research has been going on ever since starting to find new treatments or approaches to help cure it. In December 2020, the first covid vaccines were introduced after extensive research. (3) They utilized a new technology which is the mRNA-based vaccines. They have been effective with a protection rate as high as 95% and an impressive safety profile. (4) However, they have been found to cause many side effects, ranging from simple myalgias, headaches, fever, pain at the injections site. To more severe side effects such as the development of SARS and ARDS. (5) It was also found that they have multi-system side effects. CNS-related side effects were described in literature and trials. It can cause encephalitis, demyelination. And further studies are needed to unveil all the potential side effects. (6) We report a 61-year-old lady who previously had stable disease and then developed MS flare the same day she received the COVID vaccines.