With the volume of biological sequence variation data ever-rising, there is a need for lightweight and customizable tooling to facilitate the management of local collections of this variant data. An analysis of a variant collection maintained by HCI revealed a need for tooling that can manage duplicate detection and asynchronously generate suggestions for HGVS expression updates and updates to clinical significance interpretations. LocalVar was created as an institution-agnostic prototype. This proof-of-concept application can be installed locally and initialized with any comma-separated file as long as that file contains unique row identifiers and an HGVS expression and some kind of interpretation field for each record. It uses asynchronous monthly updates from ClinVar to provide update suggestions that can be accepted or declined. This tool is intended to replace the use of Excel or SQL to manage local collections of biological sequence variation.