Adding features
Because LocalVar is open-source and python-based, it can be modified by users and have its functionality greatly expanded. One such feature that was out of scope for this study would be to use other knowledge sources in addition to ClinVar. With the HGVS bin structure already in use, implementers would simply need to associate additional synonyms, interpretations, or other annotations via HGVS expressions. The source code is classed, heavily commented, and clearly separated into component files by task. This will assist with expanding the functionality of the tool. Other features could include support for HGVS expressions that use protein references, automated detection and exclusion of somatic variants, the inclusion of additional data points from ClinVar (date submitted, review status, number of submitters, etc.), support for different user types and edit permissions, or the option to submit new variant records to ClinVar directly from LocalVar.