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\begin{document}

\title{Analysis of clinical characteristics and prognostic factors of elderly
patients with renal cell carcinoma based on SEER database}



\author[1]{Xiaoyan Peng}%
\author[2]{Hui Sun}%
\author[3]{Tianyi Guo}%
\author[3]{Linxiao Wang}%
\author[1]{Wanji Guo}%
\author[4]{Yanchun Ma}%
\author[4]{Jian Yang}%
\affil[1]{Jincheng People's Hospital}%
\affil[2]{Science \& Technology Information and Strategy Research Center of Shanxi}%
\affil[3]{Shanxi Provincial Peoples Hospital}%
\affil[4]{Shanxi Medical University}%


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  \date{May 29, 2024}


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\begin{abstract}
Background: To study the difference of clinical characteristics and
prognostic factors from elderly patients with renal cell carcinoma
(RCC), the statistical analysis was carried out based on SEER database.
Methods: The relevant clinical informations of 19472 RCC patients from
2010 to 2015 were collected, and the differences of clinicopathological
characteristics and survival rate was analyzed by log-rank method and
Chi square test, respectively. Multivariate Cox regression model was
used to explore the independent risk factors affecting the long-term
survival of RCC patients. Results: Chi square test showed a significant
correlation~between older RCC patients with gender (\selectlanguage{greek}χ\selectlanguage{english}2 = 89.598) , race
(\selectlanguage{greek}χ\selectlanguage{english}2 = 129.889), TNM stage (\selectlanguage{greek}χ\selectlanguage{english}2 = 181.709), T stage (\selectlanguage{greek}χ\selectlanguage{english}2 = 145.253), and N
stage (\selectlanguage{greek}χ\selectlanguage{english}2 = 81.859). Statistics found that the proportion of 65-69-year
age group, male, white population in RCC patients was higher than that
of other year groups, female, other race, respectively. The median
survival time of 19472 RCC patients was 43 months, and 3-year and 5-
year survival rate was 75.95 \% and 66.62 \%, respectively. Univariate
survival analysis showed that the survival time was significant
correlation with gender ( \selectlanguage{greek}χ\selectlanguage{english}2 =576.5), TNM stage ( \selectlanguage{greek}χ\selectlanguage{english}2 =8206), T stage (
\selectlanguage{greek}χ\selectlanguage{english}2 =4097), N stage ( \selectlanguage{greek}χ\selectlanguage{english}2 =4849), and M stage ( \selectlanguage{greek}χ\selectlanguage{english}2 =6986). Cox
proportional hazards model analysis revealed the independent prognostic
factors related with prognosis including TNM stage (HR: 1.527), T stage
(HR: 1.044), N stage (HR: 1.334 ), and M stage (HR: 2.686). Conclusion:
Age, TNM stage, T stage, N stage, and M stage are independent prognostic
factors for RCC patients, which provides an important basis for the
clinical analysis of the prognosis of elderly RCC patients in different
ages.%
\end{abstract}%



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\verb`Main Document.doc`  available at \url{https://authorea.com/users/417375/articles/524513-analysis-of-clinical-characteristics-and-prognostic-factors-of-elderly-patients-with-renal-cell-carcinoma-based-on-seer-database}\selectlanguage{english}
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