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Legend of Figure 1
We define the inspection at the time of the intervention with the
chronobiological therapy as the first one and define the inspection
after the intervention as the second one. The 1st scores of VSRAD were
1.48 to 5.7 and the average was 3.085. The 2nd Z scores were 0.93 to
5.58 and the average was 2.727.
Legend of Figure 2
The 1st MMSE scores were 11 to 25 and the average was 16.2. The 2nd MMSE
scores after the intervention were 10 to 29 and the average was 18.5.
Legend of Figure 3
The 1st severities of Neuropsychiatric Inventory-Questionnaire (NPI-Q)
in Case 4 and 5 were 20 and 21, and the average was 20.5. The 2nd
severities of NPI-Q were 9 and 2, the average was 5.5.
Legend of Figure 4
The 1st VSRAD Z-scores were 1.48 to 5.7 and the 1st MMSE scores were 11
to 25 points. This Pearson correlation coefficient was -0.353.
Legend of Figure 5
The 2nd Z-scores were 0.93 to 5.58 and the 2nd MMSE scores were from 10
to 29 points. This Pearson correlation coefficient was -0.549.
Legend of Figure 6
The 1st Z scores were 1.48 to 5.7 and the 2nd Z scores were 0.93 to
5.58. This Pearson correlation coefficient was 0.965.
Legend of Figure 7
The 1st MMSE scores were 11 to 25 and the 2nd MMSE score were 10 to 29.
This Pearson correlation coefficient of was 0.843.
Legend of Figure 8
We achieved the recovered 0.03 to 1.28 points of VSRAD Z-score. They
were improvement rates of Z-scores (Imp Z). The Pearson correlation
coefficient between these recovered points and the 1st MMSE scores was
0.872.
Legend of Figure 9
The Pearson correlation coefficient between these Imp Z and the 2nd MMSE
scores was 0.740.
Legend of Table 1
The table shows milligram quantity of the medicines. Lansoprazole,
furosemide, and spironolactone create the activities of the autonomic
nervous system in the morning. Conversely, clonazepam and nitrazepam
create an end of the activities of autonomic nervous system at night.
Legend of Table 2
The table shows gram quantity of the Japanese Kampo Medicines (JKMs).
Ninjin-Yoei-To has an effect on decreased physical strength, fatigue,
inappetence, night sweats, coldness of hands and feet, and anemia.
Toki-Syakuyaku-San has an effect on anemia, fatigue, and edema.
Hochu-Ekki-To treats decreased physical strength, inappetence, and
gastroptosis. Bohu-Tsusho-San treats palpitation, stiff shoulder,
obesity, and constipation. Yokkan-San and Yokkan-San-Ka-Chinpi-Hange act
on irritation and insomnia. Keishi-Ka-Shakuyaku-To has an effect on
stomachache. Oren-Gedoku-To has an effect on hypertension, insomnia,
vertigo, and dermatitis. Choto-San has an effect on headache and
hypertension.
Legend of Table 3
The table shows gram quantity of the ingredients of Japanese Kampo
Medicines (JKMs). Toki, Japanese Angelica Root, creates the start of the
activity of the autonomic nervous system. Chotoko, Uncaria Hook, creates
the closure of the activity of the autonomic nervous system.