ABSTRACT
Background: In 1965 Altman achieved the hippocampal
neurogenesis in rats. In addition, when enough activities are provided
in the daytime, and it is suggested that the consolidation of the memory
during sleep will be achieved by hippocampal neurogenesis.
Aims: We show a recovery method about dementia of neurodegenerative
diseases on this article. We introduce our clinical practice of the
chronobiological therapy regarding 6 dementia cases.
Method: We provided the chronobiological therapy based on
awakening-sleep rhythm by daily medical care. We examined autonomic
nervous disorders and fluctuating cognition using physical examination.
We performed the medication to promote the changes from sleep to
awakening-activities in morning. In daytime, our occupational therapy
was set, and awakening-activities was made stable. At night we gave the
medication to make an active state decreased and stabilize deep sleep.
The clinical evaluation was carried out by psychological examination.
And Voxel-based Specific Regional Analysis System for Alzheimer’s
Disease (VSRAD) of Magnetic Resonance Imaging (MRI), which had been
already established, was performed. The conventional study in VSRAD
showed the state that the brain atrophy was progressive.
Results: About Z-score showing the hippocampal atrophy in VSRAD
we accomplished the improvement of 1.28 points from 0.03 about six
dementia cases by the chronobiological therapy. These improvements were
accompanied by the better changes of the cognitive functions.
Conclusion: We speculate that the hippocampal neurogenesis may
be derived by reconstructing awakening-sleep rhythm using the
chronobiological medicines. If neurogenesis is more dominant than
neurodegeneration, dementia associated with the neurodegeneration can be
treated.