Introduction
Sepsis is defined as the infection that causes the immune system to
attack the body, subsequently leading to an individual’s death. Sepsis
is the most common health problem because of which an increased
proportion of health resources are consumed. It is most commonly seen in
the elderly, preterm infants, or low birth weight infants.1,2 Various studies in the past have shown an
association between the polymorphism and sepsis-related mortality.3 Several biomarkers have been seen to show an
elevated level in sepsis condition like TLR4 (toll-like receptor
4) single nucleotide polymorphisms, rs4986790, and rs4986791, but not
the SERPINE1 [Serpin Peptidase Inhibitor, Clade E (Nexin,
Plasminogen Activator Inhibitor Type 1), Member 1] rs1799768
polymorphism.4-8
Tumour Necrosis factor alpha also plays a vital role in many body’s
diseased conditions like diabetes, cancer, etc. The studies conducted in
the past have produced mixed results on the role of TNF-\(\propto\)during weakened health conditions. One study reported this as a risk
factor in the North Indian population, Japanese patients, Chinese,
Turkish children. Studies in Germany and Hungary revealed a negative
correlation between preterm infants and low birth weight infants.8-19
However, there are several genomic variants of the TNF factor-\(\propto\)of which the biallelic polymorphism at position 308 is
associated with sepsis.20,21 There have been findings
suggesting a high level of correlation between TNF activity and sepsis
susceptibility and mortality. 22-23. However, there is
an equal number of evidence contradicting the
findings.24 Thus, the present meta-analysis is carried
out to assess the role of Tumour Necrosis Factor-Alpha promoter 308A/G
polymorphism in sepsis and sepsis mortality.