What does this article add?
In contrast with other formulas with high antioxidant agents our formula has been focused on the formulation of antioxidant and anti-inflammatory nutrients in terms of their dietary inflammation indices (DII). Specific amounts of some vitamins (includes vitamin A, B1, B2, B3, B5, B6, B9, C, D3) minerals (Mg, Se, Zn), and two pharmaco-nutrients (saffron and turmeric) with a negative inflammatory index score which have anti-inflammatory properties were considered. Of note, the amount of these additional nutrients in the new formula was considered between the amount of the recommended daily allowance (RDA) and the upper limit (UL) of intake. This pilot study aimed to assess the effects of this low-DII score enteral formula on metabolic, inflammatory factors and clinical outcomes of patients admitted to intensive care units (ICU).
It should be mentioned that our formula has been registered and approved as a national patent in Iran (patent number: 102502).
Clinical Relevancy Statement: Acute inflammation can be caused by an initial immune response to trauma, injury, and burn, and it can affect the body metabolism including the nutritional need and nutrient uptake. Diet can affect the body by various mechanisms such as reducing inflammatory processes, increasing levels of antioxidants, altering lipid profiles, and altering the microbial balance of the intestine. By understanding the complications of inflammatory and catabolic conditions in critically ill patients, we decided to design a new low dietary inflammatory index (DII) formula to reduce inflammatory markers in patients admitted to intensive care units (ICU).