Phase 1: low-DII-score formula
In order to design a new formula with anti-inflammatory properties, the
Karen Pharma and Food Supplement Co. (PNC) standard EnteraMeal formula
was fortified based on the DII score of nutrients. Specific amounts of
some vitamins (includes vitamin A, B1,
B2, B3, B5,B6, B9, C, D3) minerals
(Mg, Se, Zn), and two pharmaco-nutrients (saffron and turmeric) with a
negative inflammatory index score which have anti-inflammatory
properties were considered. Of note, the amount of these additional
nutrients in the new formula was considered between the amount of the
recommended daily allowance (RDA) and the upper limit (UL) of intake. In
this way, not only is the patient’s RDA provided via an average daily
intake of 2000 cc formulation powder, but the person’s inflammatory
status improves without exceeding the UL. After consulting with the
pharmaceutics advisory professors, a new formulation was designed and
sent to James R. Hebert and Nitin Shivappa (advisory professors in the
field of DII) for approval. The nutrient content of the formula is
presented in Table 1. The sources and kinds of added nutrients are
mentioned in Table 2.