What does this article add?
In contrast with other formulas with high antioxidant agents our formula
has been focused on the formulation of antioxidant and anti-inflammatory
nutrients in terms of their dietary inflammation indices (DII). Specific
amounts of some vitamins (includes vitamin A, B1, B2, B3, B5, B6, B9, C,
D3) minerals (Mg, Se, Zn), and two pharmaco-nutrients (saffron and
turmeric) with a negative inflammatory index score which have
anti-inflammatory properties were considered. Of note, the amount of
these additional nutrients in the new formula was considered between the
amount of the recommended daily allowance (RDA) and the upper limit (UL)
of intake. This pilot study aimed to assess the effects of this low-DII
score enteral formula on metabolic, inflammatory factors and clinical
outcomes of patients admitted to intensive care units (ICU).
It should be mentioned that our formula has been registered and approved
as a national patent in Iran (patent number: 102502).
Clinical Relevancy Statement: Acute inflammation can be caused
by an initial immune response to trauma, injury, and burn, and it can
affect the body metabolism including the nutritional need and nutrient
uptake. Diet can affect the body by various mechanisms such as reducing
inflammatory processes, increasing levels of antioxidants, altering
lipid profiles, and altering the microbial balance of the intestine. By
understanding the complications of inflammatory and catabolic conditions
in critically ill patients, we decided to design a new low dietary
inflammatory index (DII) formula to reduce inflammatory markers in
patients admitted to intensive care units (ICU).