Sample size
As a brand-new device, there was no RCTs to assess the diagnostic efficiency of this fluorescence colposcope previously. However, based on the reported sensitivity and specificity of conventional colposcope in detecting cervical lesions, we calculated the sample size of the conventional colposcopy group and set the sample size of the fluorescence colposcope group to be consistent with it. We estimated a sensitivity of 88% and a specificity of 85% in conventional colposcopy group, and set both the sensitivity and specificity error range to be ±0.1, type 1 error α as 0.05. The number of subjects required for each group was 90. Assuming a dropout rate of 10%, the total number of subjects for recruitment was set as 200.