Colposcopy procedures
The involved patients were randomly divided into
fluorescence colposcope group and
conventional colposcope group by
random number table method.
Neither the registrar nor
colposcopy operator participated in the random grouping work. For
patients of
fluorescence
colposcope group, 0.1%
fluorescent dye TMTP1-PEG4-ICG was apply to the cervix 30 minutes before
colposcopy as we described previously8. 2-4 cervical
sites with obvious fluorescent signal or suspected lesions were sampled
for biopsy. For patients of
conventional colposcope group,
firstly, a cotton ball containing 5%
acetic acid were applied to the
cervix for one minute. Take out the cotton ball,
observe
for 2-3 minutes, and acquire acetic acid acetowhitening response
pictures. Then wipe the cervix with a dry cotton ball and stain the
cervix with 5%
Lugol’s
iodine solution. Observe for 1-2 minutes and collect the cervix images
again. 2-4 cervical sites with abnormal visual changes
or suspected lesions were taken
for biopsy. If no suspicious lesions were observed in both of the
groups, the 3, 6, 9, 12 areas of the cervix were sampled.