Trial design
This was a prospective non-blinded randomized controlled trial, performed at Colposcopy Center of Department of Obstetrics and Gynecology, Tongji Hospital, Wuhan, China, which was a tertiary university hospital with a particular clinical and research interest in the cervical diseases. The study protocols were reviewed and approved by Ethics Committee of Tongji Hospital on September 14, 2017 (reference No. TJ-IRB20170903). And the trial was prospectively registered at ClinicalTrials.gov (NCT 03321461, Date: October 25, 2017).